how many people take glp-1 Survey: 37.5% of Stop GLP-1s after Just 3 Months how many people are taking

These effects are generally transient and tend to be most pronounced during dose escalation, but for many people, digestive changes persist throughout treatment

Commun Med 4 , 137 (2024)

2025;48:S86S127

Y.YangK.LiuQ.ZuoT.et al

The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy

Although more difficult to discriminate in neurons, exendin(9-39) appeared not to be internalized in neurons in the ARC either, as was observed with the antagonist in cells. Finally, a comparative analysis using exendin(9-39) to block GLP-1R in the ARC showed that antagonizing the ARC, rather than the PVN, significantly reduced liraglutide's weight-loss effects, confirming the ARC as the primary target for long-term weight reduction