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2025 ( Frontiers in Nutrition ), 69 GLP-1 users: 64% below iron RDA, 72% below calcium RDA

SGLT2 vs Dual Agonists: Putting Weight Loss in Context SGLT2 inhibitors like empagliflozin (Jardiance) offer modest weight reduction of approximately 4 to 6 pounds, a fraction of what dual agonists deliver

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Still, it is a pharmacodynamically expected consequence of glucagon agonism and represents a meaningful differentiator from tirzepatide

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Higher doses, while more effective for weight loss, may increase the risk of exacerbating reflux symptoms, whereas lower doses may have a lesser impact