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Efficacy and Safety of Liraglutide Versus Sitagliptin, Both in Combination With Metformin, in Chinese Patients With Type 2 Diabetes: A 26-Week, Open-Label, Randomized, Active Comparator Clinical Trial

Key timing considerations: Broader Tmax window (8 to 72 hours) means less precision in predicting peak effects Dual GIP/GLP-1 mechanism may produce a different side effect timing pattern than pure GLP-1 agonists Body aches and muscle pain may peak later than GI symptoms, around 24 to 48 hours post-injection Consider how tirzepatide affects metabolism throughout the weekly cycle The appetite suppression timeline may differ from semaglutide due to the dual mechanism Dose escalation timing: Tirzepatide starts at 2.5mg weekly, escalating to 5mg after 4 weeks