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Additional preconception optimization includes folic acid supplementation (at least 400 mcg daily per CDC recommendations), screening for nutritional deficiencies that may have developed during rapid weight loss, and ensuring adequate protein intake
The pathological mechanism might be the dysregulation of glucose metabolism, which triggered the accumulation of epicardial adipose tissue (EAT) and free fatty acids in heart, leading to myocardial lipotoxicity, oxidative stress, and mitochondrial dysfunction [41]
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This separation means neither medication significantly alters the other's blood levels or effectiveness
Plateaus are metabolic adaptation, not failure
95% CI, 4.517.5 percentage points
