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doi: 10.1016/j.psyneuen.2020.104720

The His 7 substitution by Ala resulted in a 111- to 374-fold reduction in affinity in these two studies, in contrast with only a 10-fold reduction at recombinant human GLP-1R (hGLP-1R) caused by replacing His 7 by Tyr (Xiao et al ., 2001)

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