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GLP-1 RAs consistently improved composite (secondary) renal outcomes in the CVOTs, principally driven by a reduction in new-onset albuminuria
Sci Rep 10 , 18415 (2020)
Compared to the GLP-1RA semaglutide, tirzepatide was a less potent GLP-1RA
In contrast, trials such as ELIXA, SUSTAIN-6, AMPLITUDE-O, and EXSCEL, which included broader T2DM populations without established CVD, did not show similar MI reductions [15, 17, 19, 23]
