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Shortcomings of Animal Models : While preclinical data can be suggestive, they do not always accurately predict clinical outcomes in humans due to differences in physiology, disease progression, and complex metabolic interactions that cannot be fully replicated in animal models

Consensus statement by the american association of clinical endocrinologists and american college of endocrinology on the comprehensive type 2 diabetes management algorithm2018 executive summary

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The difference is cost and accessibility, not therapeutic effectiveness

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Researchers analyzed 11 different studies to understand weight outcomes after stopping anti-obesity medications called glucagon-like peptide-1 receptor agonists, or GLP-1s, which mimic the GLP-1 hormone that is produced in the gut after eating