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Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases

Executive Maneesh Pingle discusses peptides, ADCs and the evolving CRO model

A deeper understanding of the gutmicrobiomebrain axis may ultimately enable personalized, microbiota-guided therapies that treat both the physiological and psychological dimensions of obesity and depression, marking a major step toward holistic and precision medicine.

The phase 3 TRANSCEND-T2D-1 trial evaluated the triple GIP, GLP-1, and glucagon receptor agonist in adults with type 2 diabetes inadequately controlled with diet and exercise alone.

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