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Trial Registration The predefined protocol has been registered in PROSPERO having registration number of CRD42023473991

This product should not be taken by those who are pregnant or nursing

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"It is concerning that, in some cases, people can simply go online and order these kinds of medications," researchers said.

The botanical product kratom produces opioid-like effects at high doses and is sometimes used for opioid replacement by individuals with opioid use disorder
