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Studies with longer follow-up duration are required to further investigate the potential factors associated with weight change after discontinuation of treatment

Contraindications for non-diabetic GLP-1 use include pregnancy, personal history of thyroid cancer, and certain gastrointestinal disorders
Para la formulacin oral, el estudio PIONEER 6 demostr seguridad cardiovascular (no inferioridad frente a placebo)

Oral semaglutide contains the same active medication as semaglutide injections, but it is delivered as a tablet rather than a weekly injection

In the GLP-1RA versus SGLT-2i comparison ( n = 82,789 pairs), the hazard ratios for composite outcomes suggested a smaller but still significant increase in risk for the GLP-1RA group (HR ranging from 1.188 to 1.231)

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