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For patients currently seeking weight management support, the NHS offers a range of evidence-based options

131 Evidence shows that metformin crosses the blood-brain barrier to enter the brain and confers diverse neuroprotective effects which can prove beneficial in cognitive impairment, HD (Huntingtons disease), stroke, and probably dementia

This is partly due to hormonal shiftsparticularly the drop in estrogen, which normally helps keep the body sensitive to insulin, she explains

Conflict of interest The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

This rise may relate to emerging evidence of its metabolic efficacy and weight loss benefits, which could be influencing prescribing patterns among patients with PCOS (16)

However, subjects in the GLP-1/GIP agonist group had a slightly higher rate of proliferative retinopathy and need for vitreoretinal interventions