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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Iwaya C, Nomiyama T, Komatsu S, Kawanami T, Tsutsumi Y, Hamaguchi Y, et al

Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an openlabel, randomised controlled trial

24 There is a need for drugs with equal or better efficacy and a side effect profile that allows dose maximisation

Glycemic parameters improved in all groups

Unlike Ozempic (GLP-1) or Tirzepatide (GLP-1/GIP), retatrutide activates three hormone receptors: GLP-1, GIP, and glucagon

In 2014, naltrexone/bupropion sustained release (Contrave ) and liraglutide 3 mg (Saxenda ) were approved for chronic weight management
