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From the approval of Orlistat (Xenical) in 1999, which focused on reducing dietary fat absorption, to the emergence of highly effective incretin-based therapies such as liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound), we have witnessed a fundamental shift in how obesity is understood and treated

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Our objectives were to compare incretin concentrations and rates of glucose production and gluconeogenesis in youth with type 2 diabetes before and after short-term metformin therapy compared with peers with normal glucose tolerance (NGT)