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At lower maintenance doses, weight loss averaged 1015%

The consistency of effects was also affected by trial design, with the most consistent effects seen in double-blind, placebo-controlled trials involving biopsy-confirmed MASH patients, highlighting the importance of rigorous phenotyping and potential biases in open-label studies

They inhibit the enzyme DPP-4, thus impairing the rapid degradation of two key incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Table 46 Lipid Profile (CV Outcome RCT

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