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How Does GLP-1 Work

Semaglutide itself does not directly cause vaginal dryness, but the rapid fat loss it produces can reduce estrogen levels because adipose tissue produces estrogen through aromatization

Lancet (2010) 375(9724):144756

This early evidence positions the pill as a promising oral GLP-1 medication at a time when more people want non-injection options for long-term weight management
This article examines the potential of GLP-1 RAs in MASH treatment, exploring their mechanisms of action, clinical benefits, developmental challenges, and evaluation strategies in preclinical MASH models

CVOT, cardiovascular outcome trial
