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Your healthcare provider can discuss whether switching to a different GLP-1 receptor agonist, adjusting the dose, or considering alternative therapeutic options might be appropriate for your individual circumstances

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Sample size planning was guided by previous literature on the streptozotocin (STZ) model and anticipated effect sizes, with allowance for expected attrition during the experimental period
The newer agents are more effective and have and convenient weekly dosing but they remain under patent protection, expensive, and increasingly out of reach for many patients and health plans