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Frame the submission around disease prevention: highlight how GLP-1 therapy reduces heart attack and stroke risk by 20% in clinical trials, not just weight loss

Retatrutide reduced total cholesterol by about 15-18%

Otherwise it risks spinning out of control

Acknowledgements: The authors thank Steven Lamberti, MD, for his critical advice and review of the manuscript

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For GLP-1 medications, insurers may require evidence that the patient has tried other treatments or that the medication is essential for managing weight loss in the presence of other conditions like type 2 diabetes, hypertension, or cardiovascular disease