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For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect

In a 3year SURMOUNT1 analysis, participants receiving 15 mg of tirzepatide maintained a 19.7% weight loss and showed a 93% lower risk of progressing to type 2 diabetes compared to placebo

Why can GP's like David Unwin achieve significant remission rates in PWD and yet others cannot

Lower testosterone further promotes fat storage, which further increases aromatase activity

However, not all compounding pharmacies are created equal especially when it comes to injectable GLP-1 compounds that require strict sterile manufacturing, precise dosing, and cold-chain shipping

A recent study conducted by the Harvard teaching hospital Mass Eye and Ear found an increased risk of developing non-arteritic anterior ischemic optic neuropathy (NAION) in individuals taking Ozempic