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Third, we adopted a new-user design to minimize bias from prior drug exposure and to better emulate an RCT

While pancreatic -cells are the principal therapeutic target, GLP-1Rs are widely expressed in -cells, exocrine pancreas, intestinal mucosa, renal tubules, pulmonary epithelium, selected brain nuclei, and the cardiac sinoatrial node

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Watchpoints/Conclusion Research is early and inconsistent regarding the impact of diabetes and weight loss medications on bone density and an increased likelihood of repeat spinal surgeries, with implications for the safety of joint mobilizations, the prognosis of total joint replacements, and overall bone healing

| This weight loss drug is safe and effective | This will be the biggest blockbuster drug in history Until we have the full paper to read, its good to be skeptical here