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Serotonin syndrome is rare but severe
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GLP-1
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The presence of GLP-1 receptors in these reward pathways has prompted researchers to investigate whether GLP-1 agonists might influence behaviours beyond eating, including alcohol consumption
A recent meta-analysis conducted on elderly T2D patients (15 studies, n = 11,679) evidenced that a combination of GLP-1RAs with SGLT2is (with an intervention period of at least six months), beyond demonstrating a positive safety profile, gave more benefits over monotherapy in terms of glycemic control, weight management, and CV protection [137]
