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It has been found that GLP-1R has glucose-dependent expression during osteogenic differentiation of MC3T3-E1 cells induced by bone morphogenetic protein-2 (BMP-2), and its expression increases with the increase of glucose concentration in the culture medium (Nuche-Berenguer et al., 2010)

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Interestingly, we found that, whilst exendin-4-induced SNAP-GLP-1R internalization was delayed in -arrestin-less vs

In rodent models, liraglutide stimulates calcitonin release and causes C-cell hyperplasia and tumor formation (51)