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GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) deliver remarkable weight loss but create a critical nutritional challenge: maintaining adequate protein intake

Lancet 2024;404(10467):20772093

12,19,26 Clinical trials with albiglutide for the treatment of T2DM did not show a statistically significant reduction in weight loss compared to placebo

Effect of oral semaglutide on cardiovascular parameters and their mechanisms in patients with type 2 diabetes: rationale and design of the semaglutide anti-atherosclerotic mechanisms of action study (SAMAS)

This lysosomal degradation pathway facilitates the recycling of damaged cellular components to maintain metabolic equilibrium

Unfortunately, the current trend is completely the opposite, with a steady increase in overweight and obesity affecting the youngest, putting them at very high risk of developing a veritable epidemic of cardiometabolic diseases in a few years (see our article on this subject)