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For example, analysis of four studies on suicidality in adults with bipolar disorder, major or bipolar depressive disorder or no mental illness found that liraglutide was not linked to significantly increased rates of suicidal ideation (having thoughts of suicide).Two further studies of exenatide in patients with alcohol use disorder and liraglutide in bipolar disorder found no significant difference in suicidal behaviour compared with placebo

Despite considerable methodological heterogeneity across studies, the collective findings suggest that GLP-1RAs may exert modulatory effects on alcohol-related behaviors, particularly in metabolically vulnerable populations

[DOI] [PubMed] [Google Scholar] [38].Myerson M, Paparodis RD

Garcia, M., et al

47 In addition to its direct effects on gallbladder contraction and sphincter of Oddi relaxation, CCK is involved in molecular and neuronal pathways that regulate both gallbladder function and satiety