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65 Zhu et al 66 reported a unique case where a patient developed a painful nodule on the left lower quadrant of her abdomen in response to exenatide extended-release injections

GLP-1 (Glucagon Like Peptide-1) is a transcriptional product of proglucagon gene as same as glucagon and one of gastrointestinal hormone which is secreted from L cells of lower section of the small intestine

GIP may have direct actions on adipocytes to improve lipid metabolism for instance, GIP can promote healthy fat storage in subcutaneous tissue while reducing ectopic fat deposition

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Still, one problem observed in people with high blood pressure is that their kidneys seem to hold onto more sodium, which can lead to the body retaining excess water, increasing blood pressure over time 4