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Semaglutide ameliorates metabolism and hepatic outcomes in an NAFLD mouse model

The peptide is conjugated to a C20 fatty diacid moiety, a modification that supports extended biological activity in experimental systems and sustained receptor engagement across signaling pathways

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Sensitivity analyses showed consistent results, including restricting outcomes to inpatient visits, conducting an intention-to-treat analysis, applying a prevalent new user design, and substituting SGLT2 inhibitors with dipeptidyl peptidase-4 (DPP4) inhibitors as the active comparator
