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The doses selected for Phase 3 (use our dosing calculator for personalized guidance), based on Phase 2 exposure-response analyses, were 6 mg, 12 mg, and 36 mg for obesity indications and 3 mg, 12 mg, and 36 mg for diabetes indications, reflecting a narrower and somewhat lower dose range than the Phase 2 program's maximum of 45 mg

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GLP-1 and GIP receptor physiology and metabolic effects

Tirzepatide follows a similar pattern with peak levels around 8 to 72 hours

In the SAVOR-TIMI 53 trial, which was originally performed to assess the cardiovascular safety of saxagliptin, Leibowitz and colleagues recently reported that DPP4 inhibition may attenuate the progression of diabetes (142)

Despite legitimate safety concerns and the lack of FDA (US Food and Drug Administration) approval for their use in type 1 diabetes, SGLT2i are used as adjunctive therapy in individuals with type 1 diabetes [18]