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Peak GLP-1 increases were significantly higher (~32%) after RYGB at both follow-ups (p<0.05)

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In contrast, real-world evidence suggests incremental benefits across MACE, heart failure, and renal outcomes, supporting the hypothesis that complementary mechanisms of action may translate into broader protection in clinical practice

Weight-loss drugs like Wegovy and Zepbound often cause nausea and other side effects

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