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The limited duration and small sample size may have contributed to the lack of behavioral effects, and ongoing trials are exploring repeated dosing strategies (e.g., NCT06252623, NCT06691243)

Geneva: WHO/FAO

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The observed outcomes were particularly significant in fibroblast-like synoviocytes, key players in RA pathogenesis, with the following main effects: (1) inhibition of NF-B nuclear translocation, leading to a decrease in the production of pro-inflammatory cytokines, including TNF, IL-6, IL-8, IL-1, MCP-1, and High Mobility Group Box (HMGB)-1, all of which are involved in RA progression

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