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At the genus level, liraglutide administration significantly reduced Ruminococcus and did not increase Akkermansia (Supplementary Fig

10.2337/db11-1019 103 Tomaro-DuchesneauC.LevalleyS

On the other hand, GIP-green-fluoresent-protein (GFP)-knock-in (GIP gfp/+ ) mice, in which GIP secretion is attenuated to half that of WT mice, exhibit no decrease in bone mass compared to wild-type mice, with no significant difference in blood glucose or insulin levels during OGTT after 8 weeks of HFD, although slight glucose intolerance was observed under a normal diet [18, 100]

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This requires specialized biotechnological processes to maintain the integrity and bioactivity of peptides, alongside strict quality control to ensure consistent product standards