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Peptide degradation in the gastrointestinal tract poses a significant challenge in the development of oral formulations of incretin analogues

These symptoms typically improve with continued use and dose titration, whereas true allergic reactions tend to worsen with repeated exposure

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Dietary fats are inhibited from being absorbed and this allows about 30% of the fat eaten in the meal to pass through the gut undigested

GIPR is upregulated in a subset of people with bilateral macronodular adrenal hyperplasia and food-induced Cushings syndrome [166]