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Combining prednisone with GLP-1 drugs requires careful medical oversight because corticosteroids can increase blood sugar while semaglutide lowers it

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Summary In summary, GLP-1 RA based therapies are being rigorously studied in management of MASLD in particular more advanced stages and likely will become foundational therapies in the future.

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Given these considerations, the therapeutic approach in older patients with T2D is complex, particularly in those who have functional dependence, frailty, dementia, or who are at end-of-life
