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The enhanced GI effects may cause temporary water weight shifts, while the stronger appetite suppression can lead to reduced food intake that shows up as an artificially steep drop on the scale

However, in the above-mentioned experiments, the comparison should be between exenatide (128) and GLP-1, as exenatide (2939) is truly the extra segment

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Common early effects include: Decreased appetite and reduced food cravings Smaller portions feeling satisfying sooner Significant reduction in persistent thoughts about food Lower post-meal blood sugar in patients with prediabetes or diabetes Early weight loss that accelerates with dose escalation How effective is Zepbound

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However, there may be brief fluctuations during the transition period when tirzepatide is at its starting dose