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Gastrointestinal side effects (nausea, occasional vomiting, changes in bowel habits) are often most common during this early phase as the body adapts

Case reports supporting the data Beyond the retrospective study, multiple case reports have documented TSH suppression after starting GLP-1 agonists in patients on levothyroxine

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For many patients, the experience feels like getting their appetite back to a reasonable place not an absence of hunger, but the absence of the constant, distracting noise that makes weight loss feel impossible

In contrast, patients with slow metabolism experience appetite suppression with semaglutide for longer

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