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Fueled by the FDAs approval of Wegovy for weight loss in 2021, prescriptions for GLP-1 (glucagon-like peptide-1) drugs rose 587% from 2019 to 2024 as usage expanded beyond diabetes management

This review focuses on the GLP-1R pathway, molecular mechanisms and phenotypes related to OA pathogenesis

Retatrutide: not yet available through standard channels Retatrutide is not FDA-approved

Normally, when sugar passes through the kidney filter, a tiny pump called SGLT2 grabs that sugar and pulls it back into your blood so it doesnt get wasted in urine

Both are administered via weekly subcutaneous injections, but their licensed indications differ

The mechanism appears to involve increased fat metabolism and reduced fat accumulation, potentially through AMPK activation