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This gradual titration was specifically designed to mitigate the nausea, vomiting, and diarrhea that occur more frequently with rapid dose increases

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While generally harmless and temporary, it can also be annoying and disruptive

Patients with mild OSA, normal weight, or central sleep apnea aren't in the labeled population
Kelly AS, Auerbach P, Barrientos-Perez M, Gies I, Hale PM, Marcus C, et al

By tweaking its structure, adding 13 extra amino acids and replacing one, the molecule becomes stronger and lasts longer in the body
