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Beyond preclinical evidence, clinical data underscore the therapeutic relevance of GLP-1RAs

Exenatide improved liver fat content and reduced markers of liver injury in animal models fed a high-fructose diet, highlighting the role of -catenin in mediating these effects (Zhou et al., 2020)

When these receptors are activated by butyrate, they signal L-cells to secrete GLP-1

Diabetes 59:479485 Schfer SA, Mssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

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