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These data indicate that GLP-1 receptor agonistinduced changes in local adipose tissue depots or parenchymal fat accumulation may contribute to their ability to protect the kidneys

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Tirzepatide therapy was simulated using best fit parameters k = 48 kcal/d per kg, P 0 = 830 kcal/d, and P max = 1560 kcal/d after the 12-week dose escalation period (1) resulting in an expected weight change plateau after about 24 months (Figure 1E)