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Description
Treatment allocation After the screening phase, participants will be randomized after the test day to one of the two study groups in a 1:1 ratio in accordance with a subject randomization list (SRL)

Ultimately, Coke Zero Sugar edges out Diet Coke as our preferred choice among the sugar-free options

Discuss alternative weight management options with your provider if this applies to you

The latter could have important implications for the mechanism of tirzepatide, as GIPR neurons in the hindbrain could temper the nausea induced by activation of neighboring GLP-1R neurons 67 , enabling greater systemic GLP-1R activity with manageable gastrointestinal effects

They are not equivalent in clinical practice

Tirzepatides dual mechanism may produce slightly higher rates of nausea early on, but many patients find side effects ease with gradual dose escalation
