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In a large retrospective cohort study including over 1.6 million patients with Type 2 Diabetes, with no prior diagnosis of obesity associated cancers, a significantly reduced risk in 10 out of 13 obesity associated cancers was reported with the use of GLP-1 agonists, including esophageal, colorectal, endometrial, gallbladder, kidney, liver, ovarian, pancreatic cancer, meningioma, and multiple myeloma 17

Insulin is often described as a fat-storage hormone, especially when people talk about stubborn belly fat

More serious but less common adverse effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in animal studies, though the clinical relevance in humans remains uncertain)

At $200$500 per month, a medically supervised GLP-1 program at Peak Performance is often less than what people are already spending on medications, supplements, meal delivery kits, and gym memberships that arent producing results

As a result, the extent to which observed cerebrovascular benefits represent glycaemia-independent effects versus risk-factor modification in diabetes cannot be fully disentangled

STEP 8 and STEP 3 showed similar results (101, 102)