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The majority of the reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6.1)]

PA (0.5 mmol/L)-induced endothelial dysfunction was attenuated by single treatment with higher dose of metformin (0.5 and 1.0 mmol/L) or liraglutide (30 and 100 nmol/L)

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Hypothyroidism slows metabolism, making weight management particularly challenging even with optimal levothyroxine replacement

The rest of this guide explains why, and what helps

First championed by Danish drugmaker Novo Nordisk, the Glucagon-like-peptide-1 receptor agonist (GLP-1 receptor agonist) is a newer class of drugs indicated to treat type-2 diabetes in uncontrolled traditional therapies like metformin