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[DOI] [PubMed] [Google Scholar] 23.Maddahi M., et al

That is a clinically significant reduction, comparable to what you would expect from a dedicated blood pressure medication

Most people see faster and greater weight loss compared to semaglutide

Therefore, semaglutide, tirzepatide, and retatrutide are expected to be safer and more effective treatments for MC4R-deficient obesity than setmelanotide
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June 18, 2025