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Specific concerns include post-cholecystectomy syndrome (a cluster of persistent GI symptoms in 1015% of patients) and potential interactions between GLP-1-induced motility changes and pre-existing bile acid malabsorption

Higher doses result in more visceral fat reduction, but side effects may increase

Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3 beta

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A significant proportion of breast cancer patients are overweight or obese at diagnosis, which is associated with higher recurrence and mortality rates

Testing was discontinued at this dose due to extreme reductions in food intake