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On average, patients who switched from semaglutide to orforglipron regained about 2 pounds of the weight they lost over the course of a year (almost 42 pounds total)

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Clinical Trial Results: Tirzepatide (All Forms Mounjaro, Zepbound, Compounded): Because the active ingredient is identical, effectiveness is the same: SURMOUNT-1 Trial Results (72 weeks): 15 mg dose: 22.5% average body weight loss 10 mg dose: 21.4% average body weight loss 5 mg dose: 15.0% average body weight loss 96% of patients lost at least 5% of body weight 89% of patients lost at least 10% of body weight 63% of patients lost at least 20% of body weight Real-World Effectiveness: Compounded tirzepatide produces identical results to brand-name because its the same molecule at the same doses