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While some indicate an improvement in parameters associated with depression (98), others show an increased risk, especially after longer periods of drug exposure and with the newer drugs with a longer half-life (99, 100), though some other studies indicate a higher risk with liraglutide compared to semaglutide (which in that particular study was associated with reduced risk for psychiatric events) (101)

Research areas include appetite regulation pathways, pancreatic beta cell function, hepatic lipid metabolism, and energy expenditure

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This typically occurs after the period of rapid post-surgical weight loss has stabilized

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GLP-1R agonists and perioperative outcomes 1