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At GCGR, the potency is similarly high, providing the balanced triple-agonist profile that distinguishes retatrutide from the imbalanced dual-agonist tirzepatide and from selective GLP-1R agonists like semaglutide

If this apparent difference between GLP-1 agonists is mediated by characteristics of exendin-4, a species-specific effect, or due to the dosage remains to be elucidated, as the included studies have only been performed in mice and in a small range of concentrations (14, 15)

The excitement is about the mechanism

Remarkably, there were considerable interindividual differences regarding the effects of lixisenatide on gastric emptying, with some subjects experiencing only minimal gastric emptying over the study period, such that half-emptying times could not be determined

And I just started to notice kind of, you know, mid to late last year that there were a number of studies that suggested that, you know, that they could really do a lot to alleviate, addictions and not just one type of addiction, not just say alcohol or opioids or tobacco, but essentially all of them