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Results should therefore be interpreted as average effects applicable to the indicated population, which is consistent with common practice in HTA-oriented cost-effectiveness analyses
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doi: 10.1016/s0254-6272(08)60055-2
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The problem is that the Lancet semaglutide trial studied a population defined by the intersection of AUD and obesity, a comorbid phenotype that the FDAs newly qualified endpoint framework does not specifically address
