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Weight loss slowdowns are common with GLP-1 therapy and do not always require dose increases

These effects are typically dose-dependent, most prominent during dose escalation, and tend to diminish over time

2,3,4,5 GLP-1 drugs illustrate the challenging tradeoffs inherent in healthcare access and cost

We would like to refer the reader to other articles within this themed issue of BJP , as well as the review by Knudsen and Lau (2019) about liraglutide and semaglutide

Theyre looking at the big picture while you might only see part of the puzzle

In the Phase 2 retatrutide trial published in the New England Journal of Medicine (2023), participants at the highest dose (12 mg) achieved a mean body weight reduction of approximately 24.2% over 48 weeks