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Retatrutide is the potential new champion of efficacy, offering a distinct advantage in specific metabolic comorbidities, particularly liver health, due to its GIP GLP-1 Glucagon agonist structure
Daousi, C., Pinkney, J

Within this loop, nutrient stimulation of GIP secretion enhances GLP-1 release [ Figure 1 Section A]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zhang Q, Delessa CT, Augustin R, et al

Common side effects include nausea, vomiting, diarrhoea, abdominal pain, and reduced appetite, especially when starting or increasing the dose