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Semaglutide has a half-life of approximately 7 days

Patients should be educated on the need for long-term treatment with these medications, as well as the cost and adverse reactions

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doi: 10.1210/er.2015-1146 83 TakamotoIKubotaNNakayaKKumagaiKHashimotoSKubotaTet al

If your primary issue is a plateau on semaglutide, a permanent switch to tirzepatide is supported by stronger evidence than alternating

At the highest, you need fewer than 19 units