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Multi-pronged approaches attacking obesity through completely independent mechanisms simultaneously might produce even better results than current single-medication approaches
That is a 2.5-fold increase in the likelihood of achieving a transformative weight loss outcome

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Wang W., Volkow N.D., Berger N.A., Davis P.B., Kaelber D.C., Xu R

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Clinicians should also consider alternative medical explanations for new-onset fatigue, including thyroid dysfunction, anemia, sleep apnea (which may improve or persist despite weight loss), chronic kidney disease, or cardiovascular conditions
The researchers says this body of evidence increases the need to study GLP-1 drugs as a potential approach to addressing persistent obesity in the US, which currently affects about 42 percent of the U.S
